A common approach to disease management assigns patients with particular diseases or conditions to specialists, who then concentrate only on their particular specialty. In a comprehensive patient care model, one provider treats patients in terms of all their conditions, rather than simply those that pertain to a particular specialty.

AmCare adapts to both approaches.

Only a comprehensive system like the AmCare Clinical Suite can function in a comprehensive care context; but AmCare is designed to be useful in either a comprehensive model; a single-disease, "siloed" model; or a mixed context. AmCare SmartChart is designed to serve the needs either of single-disease specialists or of comprehensive care managers. Its universal care plan functions identically whether a patient has one disease state or many, one care provider or many. When one user's changes affect others, AmCare automatically notifies them. A system administrator can define or refine a disease profile in a matter of hours or minutes – and patient summaries, flowsheets, and interventions will immediately reflect the new definition.

Therapeias believes comprehensive care approach often holds several advantages over the single-disease management approach: First, comprehensive care providers can adapt to changing administrative priorities and patient populations. They and their institutional infrastructure are not tied to a particular specialty or approach to treatment. They need not create new software nor add new staff in order to manage a new disease or condition. This allows clinics to extend their expertise into more areas of disease management. Second, continuity of care is higher. Patients with multiple conditions are cared for completely, without being assigned to many different specialists who may not communicate effectively among themselves. Patients can be treated more simply, consistently, and efficiently, with less intrusion into their lives.